Journal of Precision and Translational Gynecology

Aim

The Journal of Precision and Translational Gynecology aims to advance scientific understanding and clinical management of gynecological disorders through research that connects disease biology, diagnostic development and therapeutic decision-making. The journal provides a forum for studies that improve the interpretation of disease mechanisms, strengthen the evidence behind clinical interventions and support more individualised approaches to gynecological care. Particular emphasis is placed on research that demonstrates a meaningful connection between scientific findings and their potential application in clinical practice.

Scope

The journal welcomes original research and scholarly contributions addressing the biological, diagnostic, therapeutic and clinical dimensions of gynecology. Its scope encompasses established areas of gynecological practice alongside emerging methods that may improve disease characterisation, treatment selection and patient outcomes.

Areas of interest include:

1. Gynecological Oncology: Research on ovarian, endometrial, cervical, vulvar and vaginal malignancies, including tumour biology, molecular classification, biomarkers, early detection, treatment response, resistance mechanisms, targeted therapies and survivorship.
2. Benign Gynecological Disorders: Clinical and experimental studies of endometriosis, adenomyosis, uterine fibroids, abnormal uterine bleeding, chronic pelvic pain, ovarian disorders and other conditions affecting the female reproductive system.
3. Reproductive Endocrinology and Fertility: Polycystic ovary syndrome, ovarian function, hormonal disorders, infertility-related conditions, fertility preservation, reproductive ageing and the relationship between endocrine dysfunction and gynecological disease.
4. Molecular and Translational Gynecology: Studies investigating genetic, epigenetic, cellular, immunological and metabolic mechanisms of disease, particularly where findings support diagnostic development, therapeutic evaluation or clinically relevant hypotheses.
5. Precision Diagnostics and Biomarker Research: Discovery and validation of diagnostic, prognostic and predictive biomarkers; molecular pathology; advanced imaging; multi-omics approaches; and risk-stratification methods relevant to gynecological conditions.
6. Individualised Treatment and Therapeutic Research: Pharmacogenomics, treatment-response prediction, targeted therapies, immunotherapy, hormone-based interventions, fertility-preserving treatment and comparative evaluation of therapeutic strategies.
7. Gynecological Surgery and Procedural Innovation: Research on laparoscopic, hysteroscopic and robotic procedures, surgical outcomes, perioperative management, complications, recurrence, functional recovery and quality of life.
8. Artificial Intelligence and Computational Methods: Applications of machine learning, image analysis, computational modelling and clinical decision-support systems in gynecological diagnosis, prognosis and treatment planning. Studies should demonstrate appropriate validation and relevance to clinical or scientific questions.
9. Women's Reproductive Health Across the Life Course: Menstrual disorders, menopause, premature ovarian insufficiency, pelvic floor conditions, reproductive health complications and age-related changes with direct relevance to gynecological practice.
10. Clinical Epidemiology and Outcomes Research: Clinical trials, observational studies, real-world evidence, health-related quality of life, risk prediction, treatment effectiveness, health disparities and implementation of evidence-based gynecological care.

The journal considers original research articles, systematic reviews and meta-analyses, critical reviews, methodological studies, research protocols and selected case reports or case series that provide a clear scientific or clinical contribution. Well-designed negative studies may also be considered when they address an important research question and offer informative results.

Submissions are assessed on scientific merit, methodological soundness, ethical compliance, appropriate analysis and the strength of the conclusions. Research involving biomarkers, predictive models or emerging technologies should provide sufficient evidence to support the claims made and clearly distinguish exploratory findings from clinically validated applications. The journal encourages transparent reporting and reproducible research, with the ultimate aim of strengthening the evidence base for gynecological science and patient care.